SANE MD Medical Citations & Research

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Welcome to the SANE MD Medical Research and Citations Review page! On this page, SANE MD routinely compiles medical studies and publications that are relevant to you, the Throat Cleaner products, and topics related to this website with its’ blog and education section.

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MEDICAL CITATIONS: STUDIES & REVIEWS

  1. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  2. E H Reynolds. The Neurology of Folic Acid Deficiency. Handb Clin Neurol. 2014;120:927-43. doi: 10.1016/B978-0-7020-4087-0.00061-9.
  3. Desbats MA, Lunardi G, Doimo M, Trevisson E, Salviati L. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. J Inherit Metab Dis. 2015 Jan;38(1):145-56. doi: 10.1007/s10545-014-9749-9.
  4. Gustavo C. Ferreira and Mary C. McKenna. L-Carnitine and acetyl-L-carnitine roles and neuroprotection in developing brain. Neurochem Res. 2017 Jun; 42(6): 1661–1675.
  5. Chitu Iulia, Tudosescu Ruxandra, Leasu-Branet Costin, Voinea Liliana-Mary. CT – A Neuroprotector With Proven Effects on Glaucomatous Disease. Rom J Ophthalmol. Jul-Sep 2017;61(3):152-158. doi: 10.22336/rjo.2017.29.
  6. Colin Pritchard, Emily Rosenorn-Lanng. Neurological deaths of American adults (55-74) and the over 75′s by sex compared with 20 Western countries 1989-2010: Cause for concern. Surgical Neurology International, 2015; 6 (1): 123 DOI: 10.4103/2152-7806.161420.
  7. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  8. Mariano Malaguarnera, Lisa Cammalleri, Maria Pia Gargante. L-Carnitine Treatment Reduces Severity of Physical and Mental Fatigue and Increases Cognitive Functions in Centenarians: A Randomized and Controlled Clinical Trial. PMID: 18065594 DOI: 10.1093/ajcn/86.5.1738.
  9. M Pooyandjoo, M Nouhi, S Shab-Bidar. The Effect of (L-)carnitine on Weight Loss in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PMID: 27335245 DOI: 10.1111/obr.12436.
  10. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  11. Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.
  12. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  13. Martin Valdearcos, John D. Douglass, Megan M. Robblee, Mauricio D. Dorfman, Daniel R. Stifler, Mariko L. Bennett, Irene Gerritse, Rachael Fasnacht, Ben A. Barres, Joshua P. Thaler, Suneil K. Koliwad. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 2017; 26 (1): 185 DOI: 10.1016/j.cmet.2017.05.015.
  14. Cynthia Aranow, MD. Vitamin D and the Immune System. J Investig Med. Author manuscript; available in PMC 2012 Aug 1.
  15. Dhur A, Galan P, Hercberg S. Folate status and the immune system. Prog Food Nutr Sci. 1991;15(1-2):43-60.
  16. David Mischoulon, MD, Ph.D. Omega-3 fatty acids for mood disorders. Health Publishing.
  17. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  18. Rajiv Saini. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467.
  19. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  20. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  1. Dongsheng Cai, Tiewen Liu. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011 Dec; 1243: E1–39.
  2. Hagberg H, Gressens P, Mallard C. Inflammation during fetal and neonatal life. Ann Neurol. 2012 Apr;71(4):444-57. doi: 10.1002/ana.22620. Epub 2012 Feb 14.
  3. Tilley SK, Joseph RM. Genomic biomarkers of prenatal intrauterine inflammation. PLoS One. 2017 May 11;12(5):e0176953. doi: 10.1371/journal.pone.0176953.
  4. Abolghasem Tohidpour1, Andrey V. Morgun, Elizaveta B. Boitsova, Natalia A. Malinovskaya, Galina P. Martynova, Elena D. Khilazheva, Natalia V. Kopylevich, Galina E. Gertsog, and Alla B. Salmina. Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit. Front. Cell. Infect. Microbiol., 20 June 2017.
  5. “Predisposition to Infection in the Elderly” – Retrieved from https://www.uspharmacist.com/article/predisposition-to-infection-in-the-elderly.
  6. Larbi A, Franceschi C, Mazzatti D, et al. Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda). 2008;23:64-74.
  7. Smith PW, Roccaforte JS, Daly PB. Infection and immune response in the elderly. Ann Epidemiol.
  8. Reader BF, Jarrett BL, McKim DB, Wohleb ES, Godbout JP, Sheridan JF. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience. 2015;289:429–442.
  9. Reader BF, Jarrett BL, McKim DB, Wohleb ES, Godbout JP, Sheridan JF. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience. 2015;289:429–442.
  10. Wohleb ES, Powell ND, Godbout JP, Sheridan JF. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J Neurosci. 2013;33(34):13820–13833.
  11. Kawli, Trupti; He, Fanglian; Tan, Man-Wah (2010-01-01). “It takes nerves to fight infections: insights on Neuroimmune interactions from C. elegans”. Disease Models & Mechanisms. 3 (11–12): 721–731.
  12. Helena C.Cesar, Luciana Pellegrini Pisani. Fatty-acid-mediated hypothalamic inflammation and epigenetic programming. Jrnl of Nut Biochem. Volume 42, April 2017, Pages 1-6.
  13. Thaler JP, Yi CX, Schur EA, Guyenet SJ. et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012 Jan;122(1):153-62. doi: 10.1172/JCI59660. Epub 2011 Dec 27.
  14. Dongsheng Cai, Tiewen Liu. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011 Dec; 1243: E1–39.
  15. W Richard Bevan-Jones, Ajenthan Surendranathan. Et al. Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD). Published online 2017 Jan 5. doi: 10.1136/bmjopen-2016-013187.
  16. Daniel B. McKim, Anzela Niraula. Et al. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. Journal of Neuroscience 2 March 2016, 36 (9) 2590-2604.
  17. Emily Jacobs, Ph.D., assistant professor, psychological and brain sciences, University of California, Santa Barbara; Julie Dumas, Ph.D., associate professor, psychiatry, University of Vermont Larner College of Medicine, Burlington; Pauline Maki, Ph.D., professor, psychiatry and psychology, University of Illinois at Chicago; Sept. 28, 2016, Journal of Neuroscience.
  18. Ardura-Fabregat A, Boddeke EWGM. Et al. Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs. 2017 Dec;31(12):1057-1082.
  19. Clare H. Latta, Holly M. Brothers. Et Al. Neuroinflammation in Alzheimer’s disease; a source of heterogeneity and target for personalized therapy. Neuroscience. 2015 Aug 27; 302: 103–111.
  20. Cai Z, Hussain MD, Yan LJ. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease. Int J Neurosci. 2014 May;124(5):307-21.
  21. Dongsheng Cai, Tiewen Liu. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011 Dec; 1243: E1–39.
  22. Giuliana Martino, Valentina Rovella, Annalisa Noce. Et Al. Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity. Int J Endocrinol. 2013; 2013: 865965.
  23. Cheng Han, Matthew W. Rice. Et Al. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E32–E41.
  24. Franklin Aigbirhio, James B Rowe, and John T O’Brien. Et Al. Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD). BMJ Open. 2017; 7(1): e013187.
  25. Silvia Rossi, Valeria Studer, Caterina Motta. Et Al. Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology. 2017 Sep 26;89(13):1338-1347.
  26. Sudarshana P, Dongsheng C. Disruption of Neurogenesis by Hypothalamic Inflammation in Obesity or Aging. Rev Endocr Metab Disord. 2013 Dec; 14(4): 10.1007/s11154-013-9279-z.
  27. Dongsheng Cai, Tiewen Liu. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011 Dec; 1243: E1–39.
  28. Daniel B. McKim, Anzela Niraula. Et al. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. Journal of Neuroscience 2 March 2016, 36 (9) 2590-2604.
  29. Vezzani A, Kaufer D. Et Al. Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia. 2012 Nov;53 Suppl 6:37-44.
  30. Mikkelsen Kathleen, Apostolopoulos. Vitamin B12, Folic Acid, and the Immune System. Nutrition and Immunity. pp 103-114.
  31. E H Reynolds. Folic acid, ageing, depression, and dementia. BMJ. 2002 Jun 22; 324(7352): 1512–1515.
  32. E H Reynolds. Folic acid, ageing, depression, and dementia. BMJ. 2002 Jun 22; 324(7352): 1512–1515.
  33. E H Reynolds. Folic acid, ageing, depression, and dementia. BMJ. 2002 Jun 22; 324(7352): 1512–1515.
  34. E. H. Reynolds, P. Rothfeld. Neurological Disease associated with Folate Deficiency. Br Med J. 1973 May 19; 2(5863): 398–400.
  35. Botez MI, Fontaine F. Et Al. Folate-responsive neurological and mental disorders: report of 16 cases. Eur Neurol. 1977;16(1-6):230-46.
  36. Snowdon DA1, Tully CL. Et Al. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease. Am J Clin Nutr. 2000 Apr;71(4):993-8.
  37. Willems FF, et al. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]
  38. Eha Nurk, Helga Refsum, Ingvar Bjelland, Christian A. Drevon, Grethe S. Tell, Per M. Ueland, Stein E. Vollset, Knut Engedal, Harald A. Nygaard and A. David Smith. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study British Journal of Nutrition 2012 May Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  39. Eha Nurk, Helga Refsum, Ingvar Bjelland, Christian A. Drevon, Grethe S. Tell, Per M. Ueland, Stein E. Vollset, Knut Engedal, Harald A. Nygaard and A. David Smith. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study British Journal of Nutrition 2012 May Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  40. Garth L. Nicolson, PhD. Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements. Integr Med (Encinitas). 2014 Aug; 13(4): 35–43.
  41. Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain. National Academies Press (US); 2011.
  42. Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain. National Academies Press (US); 2011.
  43. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009 Nov;67(11):615-23.
  44. Petkov VD, Mosharrof AH. Et Al. Effect of CDP-choline on learning and memory processes in rodents. Methods Find Exp Clin Pharmacol. 1992 Oct;14(8):593-605.
  45. Knott V, de la Salle S. Et Al. Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers. Pharmacol Biochem Behav. 2015 Apr;131:119-29.
  46. McGlade E. et al., Improved Attentional Performance Following CTC Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  47. Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain. National Academies Press (US); 2011.
  48. Silveri MM et al. CT enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75.
  49. McGlade E. et al., Improved Attentional Performance Following CT Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  50. Yurelun-Todd D et al. The Effects of CT Supplementation on Motor Speed and Attention in Adolescent Males. J0urnal of Attention Disorders. 2015; 1557-1246.
  51. Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.
  52. Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.
  53. Willems FF, et al. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]
  54. Silveri MM et al. CT enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75.
  55. McGlade E. et al., Improved Attentional Performance Following CT Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.
  56. Yurelun-Todd D et al. The Effects of CT Supplementation on Motor Speed and Attention in Adolescent Males. J0urnal of Attention Disorders. 2015; 1557-1246.
  57. Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.
  58. Kobayashi, S, et al. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.
  59. Biagio R. Di Iorio, Pasquale Guastaferro. Long-term L-Carnitine Administration reduces Erythropoietin Resistance. Drug Target Insights. 2007; 2: 1–7.

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